Fumiaki Yokoi Selected Research

Trihexyphenidyl (Artane)

12/2021	Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in Dyt1 ΔGAG knock-in mice.
11/2016	Electromyographic evidence in support of a knock-in mouse model of DYT1 Dystonia.
6/2013	Engineering animal models of dystonia.
1/2012	An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.

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Fumiaki Yokoi Research Topics

Disease

19	Dystonia musculorum deformans type 1 12/2021 - 12/2005
15	Dystonia (Limb Dystonia) 12/2021 - 12/2005
5	Movement Disorders (Movement Disorder) 02/2015 - 12/2005
4	Myoclonic dystonia 02/2012 - 08/2005
3	Myoclonus (Nocturnal Myoclonus) 02/2012 - 07/2006
1	Restless Legs Syndrome (Restless Legs) 12/2020
1	Psychomotor Agitation (Akathisia) 12/2020
1	Weight Gain 01/2020
1	Dystonic Disorders (Writer's Cramp) 09/2012
1	Memory Disorders (Memory Loss) 01/2011
1	Intellectual Disability (Idiocy) 12/2009
1	Hyperthyroidism 03/2006
1	Thyroid Diseases (Thyroid Disease) 03/2006

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2005
6	Dopamine Receptors (Dopamine Receptor)IBA 01/2021 - 01/2011
5	Cholinergic Agents (Cholinergics)IBA 12/2021 - 01/2012
5	Glutamic Acid (Glutamate)FDA Link 01/2021 - 05/2010
5	Sarcoglycans (beta Sarcoglycan)IBA 02/2012 - 08/2005
4	Trihexyphenidyl (Artane)FDA LinkGeneric 12/2021 - 01/2012
4	Dopamine (Intropin)FDA LinkGeneric 01/2012 - 12/2005
3	Cholinergic Antagonists (Anticholinergics)IBA 06/2013 - 01/2012
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2015 - 01/2013
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 12/2021
1	RacloprideIBA 01/2021
1	SCH 23390IBA 01/2021
1	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 01/2021
1	LigandsIBA 01/2021
1	MuscarineIBA 01/2021
1	Neomycin FDA LinkGeneric 01/2021
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 01/2021
1	QuinpiroleIBA 01/2021
1	PotassiumIBA 12/2020
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 12/2020
1	CalciumIBA 12/2020
1	Ferritins (Ferritin)IBA 12/2020
1	EnzymesIBA 01/2020
1	TropomyosinIBA 01/2020
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	NestinIBA 01/2020
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2020
1	Messenger RNA (mRNA)IBA 02/2015
1	Pharmaceutical PreparationsIBA 01/2012
1	2- methyl- 4- carboxy- 5- hydroxy- 3,4,5,6- tetrahydropyrimidineIBA 01/2012
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2011
1	neurotrypsinIBA 12/2009
1	Serotonin (5 Hydroxytryptamine)IBA 07/2006
1	Inorganic Pyrophosphatase (Pyrophosphatase, Inorganic)IBA 03/2006
1	AcidsIBA 12/2005
1	Homovanillic AcidIBA 12/2005
1	3,4-Dihydroxyphenylacetic AcidIBA 12/2005
1	UbiquitinIBA 12/2005
1	Protein AggregatesIBA 12/2005

Therapy/Procedure

5	Therapeutics 11/2016 - 05/2010